Multiple Sclerosis

Multiple sclerosis is discussed to be associated with oxidative stress. It is unclear whether oxidative stress is the cause or more the consequence of MS, but it seems like oxidative stress has a very negative influence on the progression of the disease.

What is MS?

MS is a chronic inflammation of a specific part of nerve cells in the brain.

An immune process might be involved, which then leads to the typical lesions of the brain.

Diagnostics: typical clinical signs, MRI to show brain lesions, maybe lumbar puncture and neurophysiological testing.

Therapy is all about treating symptoms. So far there is no cure for MS.


Polachini CR, Spanevello RM, Zanini D, Baldissarelli J, Pereira LB, Schetinger MR, da Cruz IB, Assmann CE, Bagatini MD, Morsch VM. Evaluation of Delta-Aminolevulinic Dehydratase Activity, Oxidative Stress Biomarkers, and Vitamin D Levels in Patients with Multiple Sclerosis. Neurotoxicity research. 2016 Feb 1;29(2):230-42.

Kallaur AP, Reiche EM, Oliveira SR, Pereira WL, Alfieri DF, Flauzino T, de Meleck Proença C, Lozovoy MA, Kaimen-Maciel DR, Maes M. Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis. Molecular neurobiology. 2016 Jan 5:1-4.

Gonsette RE. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. Journal of the neurological sciences. 2008 Nov 15;274(1):48-53.