Nitrostative Stress

Based on the the theory of Dr. Kuklinski (a German internal medicine doctor) there are disorders of mitochondria (basically the energy center of our cells) which are not congenital, but acquired.

This so called secondary mitochondriopathy can occur in case of exposition to xenobiotics, medications like beta blocker, antibiotics, chronic stress and cranio-cervical instability. 

Nitrostative stress is diagnosed through lab parameters mostly in blood and urine. Parameters that can be measured are:

Citrulline and methylmalonic acid in urine; analysis of the exhaled air for NO, ammonia and more;  vitamins in blood, like vitamin B12, B6, D, C, K; trace elements; coenzym Q10; hormones; lactate; pyruvate and more.

Various supplements are taken to compensate the underlying deficiencies.

Micronutrients that interfere with the mitochondrial metabolism are mostly used. They catch NO and other radicals, support the B vitamins and affect nerve cells in a positive way.

For example:

B vitamins (B1, 2, 3, 6 and 12), C, E, D, K, folic acid, biotin, potassium, magnesium, zinc, selenium, iron and coenzyme Q10 are supposed to reduce nitrostative and oxidative stress and strengthen the connective tissue. Especially vitamin C is known to have a positive effect on connective tissue; whereas D is good for the bones and B12 offers a positive effect for nerve cells.

Additional Kuklinski recommends a diet such as LOGI (low glycemic insulinemic).


Please also have in mind that many Ehlers-Danlos patients have vitamin deficiencies (with or without CCI). 

My vitamins and medication to reduce oxidative and Nitrostative stress.

My vitamins and medication to reduce oxidative and Nitrostative stress.


More information (German):