Not scientific proven consequences of cervical spine instabilities


Most of the discussed correlations that follow are based on research around oxidative stress as a cause or consequence of different diseases. There are many publications about the relation between some of the later mentioned diseases and oxidative stress. However, those do not necessarily indicate that oxidative stress can be attributed to cervical spine instability. It is also not clear whether oxidative stress causes those diseases or is a consequence of them. Further aggravating is the fact that most of the later discussed diseases are unclear in their cause.

During my literature search, I found possible connections between many different conditions and oxidative stress. For example: various types of cancer, autism, ALS, MS, Alzheimer’s, Parkinson’s, autoimmune diseases, irritable bowel…

Oxidative stress describes a mechanism that plays a role in different regulatory mechanisms throughout the body.

 

Oxidative Stess / Nitrostative Stress / Secondary mitochondrial cytopathy

What is oxidative/nitrostative stress?

If there is an excessive amount of reactive oxygen compounds in our body, this metabolic situation is called oxidative stress, which can lead to mitochondrial dysfunction and to the damage of structures within our cells, for example DNA.

Similarly, if there are too many reactive nitrogen compounds, it is called nitrostative stress. Nitrostress can lead to apoptosis (natural cell death).

To diagnose oxidative or nitrostative stress we use different lab parameters.

For example:

NO in breathing air
Citrulline in urine
Methylmalonic acid
Nitrophenylacetic acid
Lipidperoxid
Isoprostane
Oxidative LDL

Furthermore, some trace elements, vitamins and other substances that are involved in protecting mechanisms, or occur as a consequence of oxidative stress, can be measrued.

Superoxide dismutase
Glutathione
Glutathione peroxidase
Alpha lipoic acid
Coenzyme Q 10
Vitamin E
Vitamin C
Vitamin D
Vitamin B1 and B6
Vitamin B12
Folic acid
Carotenoids
Zinc, Copper, Manganese, Selenium
Potassium, Magnesium
Lactate / Pyruvate

More information about the therapy of secondary mitochondropathy see here.

Secondary mitochondropathy leads to oxidative and nitrostative stress and could be acquired throughout the life (antibiotics, chemicals and other environmental influences).

However, only the primary mitochondrial dysfunctions, which are severe genetic conditions, are recognized in medicine.

 

Amytrophic lateral sclerosis / Alzheimer’s / Parkinson’s

Multiple sclerosis

Fibromyalgia

Other diseases that might be connected to oxidative stress