Nitrostative Stress

Based on the the theory of Dr. Kuklinski (a german internal medicine doctor) there are disorders of mitochondria (basically the energy center of our cells) which are not congenital but acquired.

This so called secondary mitochondriopathy can occur in case of exposition to xenobiotics, medications like beta blocker, antibiotics, chronic stress and cranio-cervical instability. 

Some naturopaths offer this therapy as well.

Nitrostative stress is diagnosed based on lab parameters mostly in blood and urine. Parameters which can be measured are:

Citrulline in urine, methylmalonic acid in urine, analysis of the exhaled air for NO, ammonia and more,  vitamines in blood like vitamin B12, B6, D, C, K; different trace elements, coenzym Q10, different hormones, lactate and pyruvate and more.

For therapy they use various supplements to compensate the underlying deficiencies.

Micronutrients which interfere with the mitochondrial metabolism, catch NO and radicals, support the B Vitamins, affect the nerve cells positive, are used.

For example, B-vitamins (B1, 2, 3, 6 and 12), C, E, D, K, folic acid, biotin, potassium, magnesium, zinc, selenium, iron, coenzyme Q10 are supposed to reduce nitrostative and oxidative stress and strengthen the connective tissue. Especially vitamin C is supposed to have a positive effect on connective tissue. D is good for the bones and B12 positive for the nerves.

Additional Kuklinski recommends a diet like LOGI (low glycemic insulinemic).


Please also have in mind that Ehlers-Danlos patients do very often have vitamine deficiencies. 



More information you can find here (German):